Abstract Search

ea0099p141 | Reproductive and Developmental Endocrinology | ECE2024

Copeptin and oxytocin in MDMA-induced hyponatremia:incidence and severity, mechanisms of action, and the effect of fluid restriction

Atila Cihan , Straumann Isabelle , Vizeli Patrick , Beck Julia , Monnerat Sophie , Holze Friederike , Liechti Matthias , Christ-Crain Mirjam

Importance: 3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a trending recreational drug but also has potential to enter clinical practice. Acute hyponatremia is a serious complication arising from ingesting even a single dose of MDMA. The assumed aetiology is a vasopressin release inducing the syndrome of inappropriate anti-diuresis combined with increased thirst causing polydipsia and thus water intoxication.Methods: Pooled analysis of...

1 shares

ea0090p151 | Pituitary and Neuroendocrinology | ECE2023

Novel provocation test with MDMA (“ecstasy’) reveals oxytocin deficiency as a new pituitary entity in patients with central diabetes insipidus – a randomized placebo-controlled trial

Atila Cihan , Holze Friederike , Murugesu Rakithan , Rommers Nikki , Hutter Nina , Varghese Nimmy , Clara Odilia Sailer , Eckert Anne , Heinrichs Markus , Liechti Matthias , Christ-Crain Mirjam

Introduction: Patients with arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus (cDI), often report psychological symptoms such as heightened anxiety levels, difficulties describing emotions, and depressed mood despite adequate treatment with desmopressin. Given the anatomical proximity, disruptions of the hypothalamic-pituitary axis causing an AVP-D could also disturb the oxytocin (OXT) system. OXT regulates socio-emotional functioning, including fear...

2 shares

Endocrine Abstracts

Copeptin and oxytocin in MDMA-induced hyponatremia:incidence and severity, mechanisms of action, and the effect of fluid restriction

Novel provocation test with MDMA (“ecstasy’) reveals oxytocin deficiency as a new pituitary entity in patients with central diabetes insipidus – a randomized placebo-controlled trial

BiosciAbstracts